COMPOSITION
Each ml contains:
Testosterone Cypionate 100mg
Testosterone Enantathe 150mg
Testosterone Phenylpropionate 100mg
3 Ampoules x 1mL
Contains: 3 mL
TESTOSTERONE CYPIONATE
Mechanism of Action and Pharmacokinetics:
The main androgen testosterone naturally, is responsible for the development and maintenance of male secondary sexual characteristics, exerting important anabolic action. The latter property contributes mainly to the acceleration of growth in puberty by stimulating bone growth and modulation of the welding process of the epiphysis of the long bones. Cypionate in the form of a prolonged therapeutic action has once been hydrolyzed to free testosterone live, being in this respect than propionate. Testosterone cypionate is highly bound to plasma proteins about 99% and 80% globulin, the albúlmina 19%, and 1% free). It is biotransformed in the liver and eliminated mainly through urine. Its half-life as intramuscular cypionate is approximately 8 days. At the target tissues is converted to 5 – alpha-dihydrotestosterone, which suppresses negative feedback to the GHR, LH and FSH.
In a normal man erythrocytes it stimulates testosterone production because it facilitates the synthesis of the erythropoiesis stimulating factors.
TESTOSTERONE ENANTHATE
Mechanism of Action and Pharmacokinetics:
Testosterone, the main sexual androgen, is responsible for the development and maintenance of male secondary sexual characteristics, exerting important anabolic action.
The latter property contributes, above all, to accelerating the process of growth in puberty by stimulating bone growth and modulation of the welding process of the epiphysis of the long bones. In the normal man stimulates the activity of RNA polymerase enzyme and the specific RNA synthesis resulting in increased protein production.
Erythrocytes stimulates testosterone production because it facilitates the synthesis of the erythropoiesis stimulating factors.
TESTOSTERONE PHENYLPROPIONATE
Mechanism of Action and Pharmacokinetics:
Testosterone is absorbed from the digestive tract through the skin and oral mucosa. However, it undergoes extensive hepatic first-pass metabolism when administered orally and therefore usually administered intramuscularly, subcu-
taneously or transdermally. It has also modified the basic molecule for testosterone orally active derivatives and prolong the duration of action. Alkylation of the 17 position to produce derivatives that are metabolized more slowly in the liver and, therefore, can be administered orally. The esterification of the hydroxyl group at 17 increased lipid solubility and leads to a slower systemic absorption when administered by intramuscular injection. The rate of absorption of esters guard relative to the size of the ester group. Testosterone esters are hydrolyzed to testosterone after absorption.
Testosterone binds approximately 80% to sex hormone binding globulin. Derivatives of 19-nostestosterona and derivatives methylated a-17 are characterized by a reduced fixing this globulin. The plasma elimination half life of testosterone is between 10 and 100 min. It is metabolized mainly in the liver by oxidation in the OH 17 group with the formation of androstenedione, which is further metabolized to androstenolona weakly androgenic, and etiocholanolone, inactive, which are excreted in the urine primarily as glucuronoconjugados and sulfates. About 6% is excreted unchanged in the faeces after undergoing enterohepatic recirculation.
Testosterone is converted to the more active derivative dihydrotestosterone in some target organs due to the 5-reductase. 19-nortestosterone derivatives are less sensitive to this enzyme. Small amounts in the body aromatized testosterone, leading to the formation of estrogen resulting in the body. Derivatives with a saturated A ring, such as Mesterolone, less estrogen are aromatized.
